Genetic tests

ONCOLOGY

DNA tests in cancer treatment

Pallas Clinic offers precision medicine, a method of patient care that allows doctors to choose the medicine that, based on the genetic understanding of each individual patient’s disease, is the best form of treatment. In this way, the best decisions are made for the treatment of the patient in a specific case, ensuring successful results.

A biopsy may be needed to determine what is in your malignancy. The sample taken during the biopsy is taken to a specialized facility, where a machine used for DNA sequencing looks for genetic changes that contribute to cancer growth. The process of looking for genetic changes in cancer is called DNA sequencing, genomic testing, molecular profiling, or tumor profiling. The test helps determine whether a drug that is specifically designed to target the genetic changes that cause cancer will help a particular patient, regardless of where the cancer is located.

Genetic testing of inherited tumors

Molecular genetic testing of inherited tumors is available at the Genetics Center iVF Riga. This type of testing is required in the following cases:

• Cancer diagnosis at a young age;
• Tumors of different locations in one patient;
• Multiple primary tumors, especially of one location (for example, breast or colorectal), in one patient;
• Several close relatives with a tumor of the same location (for example, mother, daughter and sister with breast cancer, father and son with colorectal cancer);
• An unusual manifestation of a tumor (for example, breast cancer in a man);
• Congenital abnormalities associated with inherited tumor syndromes (eg, benign skin growths).

iVF Riga gives patients the opportunity to perform genetic analyzes both for predicting the heritability of a specific oncological disease, and also for excluding the most common mutations in completely healthy people. After receiving the results, the clinic also offers genetic counseling.

TREATMENT OF INFERTILITY

DNA test infertility treatment

Genetics center iVF Riga offers complex fertility testing (genetic test for infertility investigation) for both women and men, to be performed before the artificial insemination cycle. With the help of this test, it is possible to find the answer to – why did not pregnancy occur? The obtained results can be used, even from the potential risk factors of pregnancy loss, how to specify further tactical plans for a successful outcome. Indications:

For women, if there is a history of:

• Abortus habitualis (two or more missed ab.)
• A pregnancy that has stopped for unknown reasons in the last trimester of pregnancy
• Previous IVF treatment had failed
• Miscarriage
• Premature ovarian failure

For men:

• Absence or low concentration of spermatozoa in the ejaculate
• A partner does not become pregnant during a year, living a regular sex life without using contraception
• The partner has a history of repeated early lost pregnancies (two or more missed ab.)
• Previous IVF treatment had failed

HAIR LOSS TREATMENT

TrichoTest gene tests

Rubenhair Hair Transplant Clinic and Era Esthetic Laser Dermatology Clinic offer TrichoTest, a genetic test for the treatment of hair loss. Discover genetic factors that contribute to hair loss. This test is used in the following cases:

• Wanting to understand how your genetics affect hair loss treatment.
• In patients with a family history of alopecia.
• For men and women who have tried various treatments with little or no success.

After the test, a personalized hair treatment plan and specialist support is provided. The analysis used in Fagron TrichoTest™ has been scientifically validated by global studies.

WELLNESS AND NUTRITION

NutriGen Nutrition Test

The NutriGen test from the Rubenhair Clinic and Era Esthetic analyzes 384 genetic variations associated with weight loss, exercise response, intolerance and nutrient metabolism. This unique test reveals the metabolism of the patient’s diet and is only available to the patient through healthcare professionals. The recommended personalized nutrition plan is generated by a sophisticated algorithm from more than 850 food products. Genetic test based on DNA chip technology. The test should only be done once in a lifetime, as genetic results do not change during a person’s lifetime.

Wellness DNA tests

These tests are performed to improve long-term health. There are 5 different types of tests available:

• A personalized nutritional DNA test that includes a diet and exercise plan,
• Gut microbiome test for Gutwell health to regulate appetite and weight,
• DNA test for lactose intolerance,
• Celiac Risk DNA Test,
• As well as a vitamin metabolism DNA test.

Viva Genomics: lifestyle genetic tests

With the help of the Viva Genomics DNA genetic test offered by the genetics center iVF Riga, it is possible to understand yourself more and determine the most suitable lifestyle and habits for you! This test helps to find answers to questions about proper eating habits, about vitamins – what to use, what not to use, how to fight excess weight, how to get more energy and strength to achieve the intended results and what cosmetics to use to keep the skin healthy and young . The following tests are available:

• Skin diagnostic DNA test
• Metabolic DNA test
• DNA test for vitamin metabolism
• Sports Achievement DNA Test
• Behavioral and Mental Health DNA Test

The test is performed within 2-4 weeks, an explanation of the results of the Metabolism and Vitamin metabolism tests can also be obtained in consultation with a nutritionist. The test can be purchased online or performed at a clinic on site.

Personalized medicine with genetic tests

The Anti-Aging Institute offers a wide range of genetic testing, so that each client’s health risk factors are assessed individually, the anamnesis is clarified (the patient’s and his family members’ disease history) and DNA mutations that are already encoded in people and do not change during their lifetime are investigated. Tests offered by the Anti-Aging Institute:

• WEIGHTgen – determination of genetic predisposition to obesity risk.
• Methyl Age – determination of a person’s biological age.
• MyNutrigen Proteopath – for creating the most suitable nutrition and lifestyle recommendations individually.
• MyFitnessGenes – recommendations for better athletic results.
• MyVitDGenes – to determine how genetic predisposition can affect the body’s susceptibility to infections, bone density, post-surgical scar healing, fertility and many other body functions.
• MyPharmaGenes – which drug groups are better to use for the treatment of specific diseases and how they affect the body.
• FRUCTOSE (ALDO-B) – a test for obtaining information about fructose intolerance.
• LACTOSE (MCM6) – a test for obtaining information about lactose intolerance.
• GLUTEN (HLA-DQ2/HLA-DQ8) – test for obtaining information about glucose intolerance and celiac disease.
• HISTAMINE (ABP1) – a test for obtaining information about histamine intolerance.
• Dynamic and functional tests:
  • Sleep panel.
  • Neurotransmitter panel.
  • Analysis of omega-3 fatty acids in erythrocytes.
  • Gut Health Panel.
  • Determination of oxidative stress.
  • Determination of accumulation of heavy metals.
  • Estrogen metabolites in urine.

DERMATOLOGY

DNA test for acne treatment

Some acne symptoms may have a genetic influence, with the AcneTest genetic test offered by the Rubenhair clinic and Era Esthetic, personalized acne treatment is possible by combining genetic data with the patient’s anamnesis. The results help specialists personalize acne treatment, prevent permanent scarring and hyperpigmentation. AcneTest analyzes 180 genetic variations with propensity for acne-related lesions and response to pharmacological treatment. Also, the most suitable drug formulas are recommended to achieve the best treatment result.

AESTHETIC MEDICINE

FillerTest – injection immunity test

By detecting genetic factors with the Filler Test offered by the Rubenhair clinic, it is possible to predict the complications of fillers. After the test, you will receive a full report with an explanation of your genetic characteristics and possible complications after filler injections. The analysis used in Fagron FillerTest™ has been scientifically validated by global studies.

ANTI-AGING TESTS

TeloTest for anti-aging

Rubenhair Clinic and Era Esthetic offers Fagron TeloTest, which is designed to help health professionals make specific decisions about anti-aging, especially in situations of high diagnostic efficiency, such as suspected short telomere syndromes. Telomeres are “gene tips” that regulate the course of cellular aging. They are part of the DNA and become shorter during a person’s life and determine the deterioration of the health. TeloTest uses an automated qualitative algorithm that calculates telomere length, infers biological age based on telomere length, interprets the results and relevant patient history to recommend the most suitable formulas and tips to delay the effects of aging in adult men and women.

DNA TESTS

Biological relatedness tests

It is possible to perform various tests for determining biological kinship:

• Paternity and maternity DNA tests – both anonymous and also for solving legal issues (GenEra laboratory).
• Kinship DNA tests – tests of sisters, brothers, half-sisters/half-brothers, grandmothers, grandfathers, aunts and uncles (these tests have no legal effect).

Medical DNA tests

These tests are used for diagnosis as well as for determining potential risk.

Every day in the laboratory is spent directly performing medical genetic analyzes both for diagnosing diseases and for determining or excluding the risk of certain and specific diseases. The GenEra laboratory is also the only one in Latvia that determines the status of mutation carriers for specific gene mutations. The most popular industries for testing are:

• Obstetrics and Gynecology,
• Hematology,
• Gastroenterology and Hepatology,
• Oncology,
• Neurology,
• And Pulmonology.

Also, if you are looking for other types of testing options, the GenEra lab may be able to customize the tests for your needs, contact the clinic if necessary.

Genetic consultation at the GenEra laboratory

This consultation is used to solve medical issues, the consultation lasts 1.5 hours and can be requested in the following cases:

• If medical DNA testing is performed at a GenEra laboratory (or elsewhere),
• In case of risk determination and diagnosis of genetic diseases,
• To determine the mutation carrier status.

This specific counseling is not provided for family planning issues, or before/after DNA testing during pregnancy.

VETERINARY MEDICINE

Veterinary DNA tests

GenEra is the only laboratory in Latvia that offers genetic tests for pets. All veterinary DNA tests are performed remotely by purchasing them in the e-shop. The laboratory offers only scientifically proven, useful and necessary DNA tests for each breed, testing takes place in Latvia, on average within 10 working days, using the most modern equipment and technologies.